ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2013, Vol. 44 ›› Issue (6): 829-836.doi: 10.11843/j.issn.0366-6964.2013.06.001
GENG Chun-yin1, 2, YANG Lian-yu3, YAN Chang-guo2, REN Li-ping1,ZHOU Zhen-ming1, MENG Qing-xiang1*
Received:2012-11-08
Online:2013-06-23
Published:2013-06-23
CLC Number:
GENG Chun-yin, YANG Lian-yu, YAN Chang-guo, REN Li-ping,ZHOU Zhen-ming, MENG Qing-xiang. The Main Function and Secretion Regulation of Des-acyl Ghrelin and Obestatin Derived from Ghrelin Gene[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2013, 44(6): 829-836.
|
AKAMIZU T，SHINOMIYA T，IRAKO T，et al．Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay［J］．J Clin Endocrinol Metab，2005，90(1)：6-9. KANAMOTO N，AKAMIZU T，TAGAMI T，et al．Genomic structure and characterization of the 50-flanking region of the human ghrelin gene［J］．Endocrinology，2004，145：4144-4153. HOSODA H，KOJIMA M，MATSUO H，et al．Purification and characterization of rat des-Gln14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor［J］．J Biol Chem，2000，275：21995-22000. SOARES J B，LEITE-MOREIRA A F．Ghrelin，des-acyl ghrelin and obestatin：Three pieces of the same puzzle［J］．Ｐeptides，2008，29：1255-1270. HOSODA H，KOJIMA M，MIZUSHIMA T，et al．Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by posttranslational processing［J］．J Biol Chem，2003，278：64-70. YANG J，BROWN M S，LIANG G，et al．Identification of the acyltransferase that octanoylates ghrelin，an appetite-stimulating peptide hormone［J］．Cell，2008，132：387-396. KANG K，SCHMAHL J， LEE J M，et al．Mouse ghrelin-O-acyltransferase (GOAT) plays a critical role in bile acid reabsorption［J］．FASEB，2012，26：259-271. ZHANG J V，REN P G，AVSIAN-KRETCHMER O，et al．Obestatin，a peptide encoded by the ghrelin gene，opposes ghrelin’s effects on food intake［J］．Science，2005，11：996-999. CHANOINE J P，WONG A C．Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fasting［J］．Endocrinology，2004，145：3813-3820. GHELARDONI S，CARNICELLI V，FRASCARELLI S，et al．Ghrelin tissue distribution: comparison between gene and protein expression［J］．J Endocrinol Invest，2006，29：115-121. GNANAPAVAN S，KOLA B， BUSTIN S A，et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor，GHS-R，in humans［J］. J Clin Endocrinol Metab，2002，87：2988-2991. LEAR P V，IGLESIAS M J，FEIJÓO-BANDÍN S，et al. Des-acyl ghrelin has specific binding sites and different metabolic effects from ghrelin in cardiomyocytes［J］．Endocrinology，2010，151(7)：3286-3298. CHANOINE J P，WONG A C，BARRIOS V．Obestatin， acylated and total ghrelin concentrations in the perinatal rat pancreas［J］．Hormone Res，2006，66：81-88. DUN S L，BRAILOIU G C，BRAILOIU E，et al．Distribution and biological activity of obestatin in the rat［J］．J Endocrinol，2006，191：481-489. ZHAO C M，FURNES M W，STENSTRO M B，et al．Characterization of obestatin-and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: an immunohistochemical and electron-microscopic study［J］． Cell Tissue Res，2007，331：575-587. ZHANG J V，JAHR H，LUO C W，et al．Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39［J］．Mol Endocrinol，2008，22，6：1464-1475. LI J B，ASAKAWA K，CHENG K C，et al．Biological effects of obestatin［J］．Endocrine，2011，39：205-211. MALAGO′N M M，LUQUE R M，RUIZ-GUERRERO E，et al．Intracellular signalling mechanisms mediating ghrelinstimulated growth hormone release in somatotropes［J］．Endocrinology，2003，144：5372-5380. ARIYASU H，TAKAYA K，IWAKURA H，et al．Transgenic mice overexpressing des-acyl ghrelin show small phenotype［J］．Endocrinology，2005，146：355-364. NOGUEIRAS R，PFLUGER P，TOVAR S，et al．Effects of obestatin on energy balance and growth hormone secretion in rodents［J］．Endocrinology，2007，148：21-26. SAMSON W K，WHITE M M，PRICE C，et al．Obestatin acts in brain to inhibit thirst［J］．Am J Physiol Regul Int Comp Physiol，2007，292：R637-643. ZIZZARI P，LONGCHAMPS R，EPELBAUM J，et al．Obestatin partially affects ghrelin stimulation of food intake and GH secretion in rodents［J］．Endocrinology，2007，148：1648-1653. NEARY N M，DRUCE M R，SMALL C J,et al．Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect［J］．Gut，2006，55：135. INHOFF T，MONNIKES H，NOETZEL S，et al．Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats［J］．Peptides，2008，29：2159-2168. TACHIBANA T，TANAKA M，KAIYA H．Central injection of des-acyl chicken ghrelin does not affect food intake in chicks［J］．General Comp Endocrinol，2011，171(2)：183-188. LAGAUD G J，YOUNG A，ACENA A，et al．Obestatin reduces food intake and suppresses body weight gain in rodents［J］．Biochem Biophy Res Commun，2007，357：264-269. SEOANE L M，AL-MASSADI O，PAZOS Y，et al．Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats［J］．J Endocrinol Invest，2006，29：RC13-15. BRUNETTI L， LEONE S，ORLANDO G，et al．Effects of obestatin on feeding and body weight after standard or cafeteria diet in the rat［J］．Peptides，2009，30：1323-1327. ANNEMIE V D，DEBBY V D，VALENTIJN V，et al．Central administration of obestatin fails to show inhibitory effects on food and water intake in mice［J］．Regul Pept，2009，156：77-82. QADER S S，HAKANSON R，REHFELD J F，et al．Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin：a study on isolated islets from mouse and rat pancreas［J］．Regul Pept，2007，146：230-237. HEIJBOER A C，VAN DEN HOEK A M，PARLEVLIET E T，et al．Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice［J］．Diabetologia，2006，49：732-738. PATEL A D，STANLEY S A，MURPHY K G，et al．Ghrelin stimulates insulin-induced glucose uptake in adipocytes［J］．Regul Pept，2006，134：17-22. THOMPSON N M，GILL D A，DAVIES R，et al．Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor［J］．Endocrinology，2004，145：234-242. MUCCIOLI G，PONS N，GHE’C，et al．Ghrelin and des-acyl ghrelin both inhibit isoproterenolinduced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor［J］．Eu J Pharm，2004，498：27-35. RODRIGUEZ A，GOMEZ-AMBROSI J，CATALAN V，et al．Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes［J］．Int J Obesity，2009，33：541-552. LEAR P V，IGLESIAS M J，FEIJOO-BANDIN S，et al．Des-acyl ghrelin has specific binding sites and different metabolic effects from ghrelin in cardiomyocytes［J］．Endocrinology，2010，151：3286-3298. MIEGUEU P，ST PIERRE D，BROGLIO F, et al．Effect of desacyl ghrelin, obestatin and related peptides on triglyceride storage，metabolism and GHSR signaling in 3T3-L1 adipocytes［J］．J Cell Biochem，2011，112：704-714. SAKURADA T，RO S，ONOUCHI T，et al．Comparison of the actions of acylated and desacylated ghrelin on acid secretion in the rat stomach［J］．J Gastroenterol，2010，45(11)：1111-1120. CHEN C Y，CHAO Y，CHANG F Y，et al．Intracisternal des-acyl ghrelin inhibits food intake and non-nutrient gastric emptying in conscious rats［J］．Int J Mol Med，2005，16：695-699. ASAKAWA A，ATAKA K，FUJINO K，et al．Ghrelin family of peptides and gut motility［J］．J Gastroenterol Hepatol，2011，16(s3)：73-74. ATAKA K，INUI A，ASAKAWA A，et al．Obestatin inhibits motor activity in the antrum and duodenum in the fed state of conscious rats［J］．Am J Physiol Gastroint Liver Physiol，2008，294：G1210-1218. FUJIMIYA M，ATAKA K，ASAKAWA A，et al．Regulation of gastroduodenal motility：Acyl ghrelin，Des-acyl ghrelin and Obestatin and hypothalamic peptides［J］．Digestion，2012，85：90-94. FUJIMIYA M，ASAKAWA A，ATAKA A，et al．Different effects of ghrelin, des-acyl ghrelin and obestatin on gastro duodenal motility in conscious rats［J］．World J Gastroenterol，2008，14：6318-6326. FUJIMIYA M，ASAKAWA A，ATAKA K，et al．Ghrelin, des-acyl ghrelin, and obestatin: regulatory roles on the gastrointestinal motility［J/OL］．Int J Pept，2010，doi：10.1155/2010/305192. STENGEL A，WANG L X， TACHÉ Y．Stress-related alterations of acyl and desacyl ghrelin circulating levels： Mechanisms and functional implications［J］．Peptides，2011，32(11)：2208-2217. PACIFICO L，POGGIOGALLE E，COSTANTINO F，et al．Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome［J］．Eu J Endocrinol，2009，161：861-870. GUO Z F，ZHENG X，QIN Y W，et al．Circulating preprandial Ghrelin to Obestatin ratio is increased in human obesity［J］． J Clin Endocrinol Metab，2007，92：1875-1880. BANG A S，SOULE S G，YANDLE T G，et al．Characterisation of proghrelin peptides in mammalian tissue and plasma［J］．J Endocrinol，2007，192：313-323. DU G，SHI Z，XIA D，et al．Cysteamine improves growth performance and gastric ghrelin expression in preweaning piglets［J］．Domest Anim Endocrinol，2012，42(4)：203-209. YANG W，WANG J，ZHU X，et al．High lever dietary copper promote Ghrelin gene expression in the fundic gland of growing pigs［J/OL］．Biol Trace Elem Res，2012，doi：10.1007/s12011-012-9477-7. NISHI Y，HIEJIMA H，HOSODA H，et al．Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin［J］．Endocrinology，2005，146：2255-2264. NISHI Y，HIEJIMA H，MIFUNE H，et al．Developmental changes in the pattern of ghrelin’s acyl modification and the levels of acyl-modified ghrelins in murine stomach［J］．Endocrinology，2005，146：2709-2715. MANUEL D，GAHETEA， CÓRDOBA-CHACÓNA J，et al．Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus，pituitary，and stomach［J］．Mol Cell Endocrinol，2010，317：154-160. SATOU M，NISHI Y，YOH J，et al．Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium［J］．Endocrinology，2010，151(10)：4765-4775. |
| [1] | LIU Jie, CONG Wei, ZHAO Mindie, ZHAO Ruqian. Expression of GR and FKBP5 in Hippocampus and Hypothalamus of Arbor Acres and Rugao Yellow Broiler Chickens and Its Relationship with Stress Sensitivity [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(11): 4766-4776. |
| [2] | DAI Lingli, LIU Zaixia, GUO Lili, YANG Yanda, CHANG Chencheng, WANG Yu, SHI Caixia, WANG Yuzhen, ZHANG Wenguang. β-Hydroxybutyrate Mediated Epigenetic Modification and Its Molecular Mechanism of Regulating Inflammation [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4095-4104. |
| [3] | ZHAO Huiying, YU Shiqiang, ZHAO Yuchao, JIANG Linshu. Mechanism of Liver-Adipose Tissue Crosstalk in the Development of Fatty Liver in Periparturient Cows [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(10): 4105-4116. |
| [4] | CAO Xiyue, JI Xiaoxia, ZHANG Chonghao, ZHANG Yafeng, CHEN Yutao, ZHANG Yuanshu. Diminazene Aceturate Alleviates Pulmonary Fibrosis in Mice by Endogenous Activation of ACE2 to Inhibit AngⅡ-TGF-β1 Pathway [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(6): 2631-2640. |
| [5] | YANG Heng, LI Licai, FU Lin, XU Huihao, ZHANG Dezhi, LI Qianyong. Effect of Prostaglandin D2 on Endocrine Function and Expression of Apoptosis-related Genes in Goat Luteal Cells [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(4): 1652-1663. |
| [6] | JIN Meilin, LI Taotao, SUN Dongxiao, WEI Caihong. Research Progress of Epigenetic Regulation in Fat Deposition Mechanism of Livestock and Poultry [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 855-867. |
| [7] | YE Qianwen, CHEN Zhuo, LI Xin, SUN Yawei, JIN Xiaoye, LI Ziqian, WUMAIERJIANG·Yahefu, ZHONG Qi, MA Xuelian, YAO Gang. Dynamic Changes of Gut Microbiota Composition and Its Predicted Metabolism Function in One-month-old Sucking Lambs [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(3): 1095-1108. |
| [8] | ZHANG Xiyu, ZHAI Pin, WANG Fan, DAI Yingying, ZHAO Bohao, CHEN Yang, WU Xinsheng. Expression and Function of KRT 16 in Hair Follicle Development of Angora Rabbit [J]. Acta Veterinaria et Zootechnica Sinica, 2023, 54(1): 157-167. |
| [9] | LIU Zhihao, JIA Peng, LAI Qi, DONG Lifeng, WU Qiujue, GAO Yanhua, TIAN Zhonghong, DIAO Qiyu. Characteristics of Rumen Fermentation and Methane Production in Different Parity Dry Cows [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(12): 4296-4305. |
| [10] | CAO Xiyue, FU Yali, XIE Nana, ZHANG Yafeng, ZHANG Yuanshu. Inhibitory Effect and Mechanism of Endogenous Activation of Angiotensin Converting Enzyme 2 by Diminazene Aceturate on Cell Lipid Deposition [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(8): 2729-2738. |
| [11] | GUO Wenliang, XU Yuanqing, JIN Xiao, SHI Binlin. Moderating Role of Heat Shock Protein Under Inflammatory Response and Oxidative Stress Caused by Cold Stress [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1668-1677. |
| [12] | YUAN Jing, ZHANG Xinxin, ZHOU Di, YANG Shuai, ZHOU Jiayan, LIANG Aixin, YANG Liguo. Evaluation of the Effect of SS and CST Dual-expression DNA Vaccines with Attenuated Salmonella as Carrier in Immunizing Calves through Different Routes [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(6): 1914-1924. |
| [13] | SUN Yanjin, XUE Ya’nan, ZHONG Tao, WANG Linjie, LI Li, ZHANG Hongping, ZHAN Siyuan. The Function of HuR and Its Regulation on Muscle Growth and Development [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(5): 1345-1353. |
| [14] | DING Jun, FU Zilin, HE Junhao, DUAN Xiaowei, MA Lu, BU Dengpan. Research Progress of Milk-derived Exosomes [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(4): 1019-1029. |
| [15] | LI Yaqi, WANG Xianzhong, ZHANG Jiaojiao. Research Progress of Cell Proliferation and Apoptosis Regulated by Non-thermal Plasma and Its Application in Animal Husbandry [J]. Acta Veterinaria et Zootechnica Sinica, 2022, 53(1): 1-10. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
